Penny Proud
Voiced by Kyla Pratt, The 14-year-old main character, she is usually embarrassed by the way her parents act. She enjoys hanging out with her friends, even though they have gotten her into trouble many times. She listens to and respects her parents, but often caves into peer pressure.

Oscar Proud
Voiced by Tommy Davidson, Penny's overprotective father, what some may call a born loser and owner of Proud Snacks, which makes anybody who eats them sick, except Peabo, who is the only person who likes them.

Trudy Proud
Voiced by Paula Jai Parker, Penny's ambitious, loving and moral-teaching mother who is respectful of others, Trudy works as a veterinarian. Since she makes more money than Oscar[dubious – discuss], she asserts dominance over him at times.

BeBe and CeCe Proud, and Puff the Dog
Voiced by Tara Strong, Penny's trouble-making three-year-old twin little siblings, Puff is Sugar Mama's pet poodle who is often tortured by BeBe and CeCe.

Suga Mama Proud
Voiced by Jo Marie Payton, Penny's wrestling loving hip grandma who does Tae-bo. She constantly insults, discourages and beats up Oscar, but she does love him deep down.

Dijonay Jones
Voiced by Karen Malina White, Penny's plump, and somewhat eccentric best friend who loves Sticky Webb.

Sticky Webb
Voiced by Orlando Brown, Penny's friend and Dijonay's love interest, though he dislikes her rather strong come-ons.

Zoey Howzer
Voiced by Soleil Moon Frye, Penny's nerdy friend.

LaCienega Boulevardez
Voiced by Alisa Reyes, Penny's on again/off again friend. She speaks Spanish and is extremely rude to Penny (and makes sure the adults don't know that).